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Article

The process of malignant progression in human breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 1990

Clarke R, Dickson R B, Brünner N

Abstract excerpt

Malignant progression in breast cancer represents the processes through which localized, hormone-dependent tumor cells become resistant to endocrine manipulations and metastasize to sites distant from the primary tumor. By selection in ovariectomized athymic nude mice, we have isolated a variant (MIII) of the hormone-dependent, poorly invasive, human breast cancer cell line MCF-7. MIII cells have lost their...

Topics

Animals
Breast Neoplasms
Cell Transformation, Neoplastic
Estrogens
Female
Humans
Mice
Mice, Nude
Phenotype
Tumor Cells, Cultured

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2083184
DOI: 10.1093/oxfordjournals.annonc.a057790

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2083184-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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