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Article

Hormone resistance, invasiveness, and metastatic potential in breast cancer.

Breast cancer research and treatment - 1 Jan 1993

Clarke R, Thompson E W, Leonessa F, Lippman J, McGarvey M, Frandsen T L, Brünner N

Abstract excerpt

Critical phenotypic changes that occur during the progression of breast cancer include the loss of hormone-dependence, acquired resistance to systemic therapies, and increased metastatic potential. We have isolated a series of MCF-7 human breast cancer variants which exhibit hormone-independent growth, antiestrogen resistance, and increased metastatic potential. Analysis of the phenotypes of these variants...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8435478
DOI: 10.1007/BF01833263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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