Article
The biology of breast tumor progression. Acquisition of hormone independence and resistance to cytotoxic drugs.
Acta oncologica (Stockholm, Sweden) - 1 Jan 1992
Leonessa F, Boulay V, Wright A, Thompson E W, Brünner N, Clarke R
Abstract excerpt
Many breast tumors appear to follow a predictable clinical pattern, being initially responsive to endocrine therapy and to cytotoxic chemotherapy but ultimately exhibiting a phenotype resistant to both modalities. Using the MCF-7 human breast cancer cell line as an example of an 'early' phenotype (estrogen and progesterone receptor positive, steroid responsive, low metastatic potential), we have isolated and...
Topics
- Animals
- Breast Neoplasms
- Colchicine
- Drug Resistance
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Methotrexate
- Mice
- Mice, Nude
- Models, Biological