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Article

The biology of breast tumor progression. Acquisition of hormone independence and resistance to cytotoxic drugs.

Acta oncologica (Stockholm, Sweden) - 1 Jan 1992

Leonessa F, Boulay V, Wright A, Thompson E W, Brünner N, Clarke R

Abstract excerpt

Many breast tumors appear to follow a predictable clinical pattern, being initially responsive to endocrine therapy and to cytotoxic chemotherapy but ultimately exhibiting a phenotype resistant to both modalities. Using the MCF-7 human breast cancer cell line as an example of an 'early' phenotype (estrogen and progesterone receptor positive, steroid responsive, low metastatic potential), we have isolated and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1622625
DOI: 10.3109/02841869209088890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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