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Article

Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression.

Breast cancer research and treatment - 1 Jan 1994

Clarke R, Skaar T, Baumann K, Leonessa F, James M, Lippman J, Thompson E W, Freter C, Brunner N

Abstract excerpt

We have established and characterized a series of variant cell lines in which to identify the critical factors associated with E2-induced malignant progression, and the acquisition to tamoxifen resistance in human breast cancer. Sublines of the hormone-dependent MCF-7 cell line (MCF7/MIII and MCF7/LCC1) form stable, invasive, estrogen independent tumors in the mammary fat pads of ovariectomized athymic nude mice....

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Identifiers

PMID: 7881102
DOI: 10.1007/BF00666157

Genes

PGR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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