Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression.

doi:10.1007/BF00666157

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Article

Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression.

Breast cancer research and treatment - 1 Jan 1994

Clarke R, Skaar T, Baumann K, Leonessa F, James M, Lippman J, Thompson E W, Freter C, Brunner N

Abstract excerpt

We have established and characterized a series of variant cell lines in which to identify the critical factors associated with E2-induced malignant progression, and the acquisition to tamoxifen resistance in human breast cancer. Sublines of the hormone-dependent MCF-7 cell line (MCF7/MIII and MCF7/LCC1) form stable, invasive, estrogen independent tumors in the mammary fat pads of ovariectomized athymic nude mice....

Topics

Adenocarcinoma
Animals
Breast Neoplasms
Clone Cells
Cocarcinogenesis
Disease Progression
Drug Resistance
Estrogens
Female
Gene Expression Regulation, Neoplastic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Nude

Neoplasm Transplantation

Neoplasms, Hormone-Dependent

Phenotype

Progesterone

Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 7881102
DOI: 10.1007/BF00666157

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7881102-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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