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Article

Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012

El Hadri Khadija, Mahmood Dler Faieeq Darweesh, Couchie Dominique, Jguirim-Souissi Imene, Genze Felicitas, Diderot Vimala, Syrovets Tatiana, Lunov Oleg, Simmet Thomas, Rouis Mustapha

Abstract excerpt

OBJECTIVE: Oxidative stress is believed to play a key role in cardiovascular disorders. Thioredoxin (Trx) is an oxidative stress-limiting protein with anti-inflammatory and antiapoptotic properties. Here, we analyzed whether Trx-1 might exert atheroprotective effects by promoting macrophage differentiation into the M2 anti-inflammatory phenotype. METHODS AND RESULTS: Trx-1 at 1 μg/mL induced downregulation of...

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Source

Identifiers

PMID: 22516068
DOI: 10.1161/ATVBAHA.112.249334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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