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Article

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

Journal of neurochemistry - 1 Oct 2008

Soriano Francesc X, Léveillé Frédéric, Papadia Sofia, Higgins Larry G, Varley James, Baxter Paul, Hayes John D, Hardingham Giles E

Abstract excerpt

Peroxiredoxins are an important family of cysteine-based antioxidant enzymes that exert a neuroprotective effect in several models of neurodegeneration. However, under oxidative stress they are vulnerable to inactivation through hyperoxidation of their active site cysteine residues. We show that in cortical neurons, the chemopreventive inducer 3H-1,2-dithiole-3-thione (D3T), that activates the transcription...

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Identifiers

PMID: 18761713
DOI: 10.1111/j.1471-4159.2008.05648.x
PMCID: PMC2635540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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