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Article

Early growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcription.

The Journal of biological chemistry - 28 Jan 2005

Mostecki Justin, Showalter Brian M, Rothman Paul B

Abstract excerpt

Suppressor of cytokine signaling (SOCS)-1 is a critical regulator of lipopolysaccharide (LPS) tolerance and LPS-induced cytokine production. The mechanisms regulating the transcription of SOCS-1 in response to LPS are not entirely understood. Functional analysis of the SOCS-1 promoter demonstrates that early growth response-1 (Egr-1) is an important transcriptional regulator of SOCS-1. Two Egr-1 binding sites are...

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Identifiers

PMID: 15545275
DOI: 10.1074/jbc.M408938200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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