Co-evolution networks of HIV/HCV are modular with direct association to structure and function

Abstract excerpt

Mutational correlation patterns found in population-level sequence data for the Human Immunodeficiency Virus (HIV) and the Hepatitis C Virus (HCV) have been demonstrated to be informative of viral fitness. Such patterns can be seen as footprints of the intrinsic functional constraints placed on viral evolution under diverse selective pressures. Here, considering multiple HIV and HCV proteins, we demonstrate that t...

Topics

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• Hepatitis C
• HIV Core Protein p24
• HLA Antigens
• Immune System
• nef Gene Products, Human Immunodeficiency Virus
• Normal Distribution
• Principal Component Analysis
• Protein Domains

Identifiers and source

Literature Corpus work

d1048cec-08ab-5950-b91f-21071a541db9

DOI

10.1101/307033