Article
A comparison of methods to detect and quantify the markers of antimalarial drug resistance.
The American journal of tropical medicine and hygiene - 1 Sept 2010
Hastings Ian M, Nsanzabana Christian, Smith Tom A
Abstract excerpt
We compare, contrast, and evaluate methods to quantify genetic markers of antimalarial drug resistance. Frequency estimates should be reported along with crude prevalence. There are four main potential methods to estimate frequencies in blood samples: simple counting of single nucleotide polymorphisms (SNPs) and haplotypes in samples with multiplicity of infection (MOI) = 1; SNP counting in samples with MOI < or...
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