Article
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
Malaria journal - 17 Mar 2014
Taylor Aimee R, Flegg Jennifer A, Nsobya Samuel L, Yeka Adoke, Kamya Moses R, Rosenthal Philip J, Dorsey Grant, Sibley Carol H, Guerin Philippe J, Holmes Chris C
Abstract excerpt
BACKGROUND: Reliable measures of anti-malarial resistance are crucial for malaria control. Resistance is typically a complex trait: multiple mutations in a single parasite (a haplotype or genotype) are necessary for elaboration of the resistant phenotype. The frequency of a genetic motif (proportion of parasite clones in the parasite population that carry a given allele, haplotype or genotype) is a useful measure...
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