Article
Assessment of different genotyping markers and algorithms for distinguishing Plasmodium falciparum recrudescence from reinfection in Uganda.
Scientific reports - 5 Feb 2025
Mwesigwa Alex, Golumbeanu Monica, Jones Sam, Cantoreggi Sara L, Musinguzi Benson, Nankabirwa Joaniter I, Bikaitwoha Everd Maniple, Kalyango Joan N, Karamagi Charles, Plucinski Mateusz, Nsobya Samuel L, Nsanzabana Christian, Byakika-Kibwika Pauline
Abstract excerpt
Antimalarial therapeutic efficacy studies are vital for monitoring drug efficacy in malaria-endemic regions. The WHO recommends genotyping polymorphic markers including msp-1, msp-2, and glurp for distinguishing recrudescences from reinfections. Recently, WHO proposed replacing glurp with microsatellites (Poly-α, PfPK2, TA1). However, suitable combinations with msp-1 and msp-2, as well as the performance of...
Topics
- Uganda
- Algorithms
- Humans
- Plasmodium falciparum
- Malaria, Falciparum
- Microsatellite Repeats
- Genotype
- Protozoan Proteins
- Recurrence
- Merozoite Surface Protein 1
- Antimalarials
- Antigens, Protozoan