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Article

Efficacy, Safety, and Selection of Molecular Markers of Drug Resistance by Two ACTs in Mali

1 Mar 2008

Abstract excerpt

We conducted a randomized single-blinded trial comparing the efficacy and safety of artesunate (AS) + amodiaquine (AQ, 3 days) versus AS (3 days) + sulfadoxine-pyrimethamine (SP, single dose) versus AS monotherapy (5 days) in Southern Mali. Uncomplicated malaria cases were followed for 28 days. Molecular markers of drug resistance were determined. After identification of recrudescences by genotyping, both...

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PMID: 18337343
DOI: 10.4269/ajtmh.2008.78.455

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