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Article

MOIRE: a software package for the estimation of allele frequencies and effective multiplicity of infection from polyallelic data.

Bioinformatics (Oxford, England) - 1 Oct 2024

Murphy Maxwell, Greenhouse Bryan

Abstract excerpt

MOTIVATION: Malaria parasite genetic data can provide insight into parasite phenotypes, evolution, and transmission. However, estimating key parameters such as allele frequencies, multiplicity of infection (MOI), and within-host relatedness from genetic data is challenging, particularly in the presence of multiple related coinfecting strains. Existing methods often rely on single nucleotide polymorphism (SNP)...

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PMID: 39423091
DOI: 10.1093/bioinformatics/btae619
PMCID: PMC11524891

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