Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 2008

Kanai Yoshikatsu

Abstract excerpt

Urate, a naturally occurring product of purine metabolism, is present at higher levels in human blood than in other mammals, because humans have an effective renal urate reabsorption system in addition to their evolutionary loss of hepatic uricase by mutational silencing. The urate transporter URAT1 encoded by SLC22A12 is a urate anion exchanger regulating blood urate levels. URAT1 is localized in the apical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cation Transport Proteins
Share to Kidney Tubules, Proximal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lactic Acid

Share to Monocarboxylic Acid Transporters

Share to Organic Anion Transporters

Share to Organic Cation Transport Proteins

Share to Uric Acid

Source

Identifiers

PMID: 18409511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters].PMID 18409511Read ↗

[Urate transporter and renal hypouricemia].Semantic proximity Read ↗

Molecular identification of a renal urate anion exchanger that regulates blood urate levels.Semantic proximity Read ↗

Renal urate handling: clinical relevance of recent advances.Semantic proximity Read ↗

[Molecular biology of urate transporter].Semantic proximity Read ↗

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies.Semantic proximity Read ↗

[Abnormalities in urate metabolism: concept and classification].Semantic proximity Read ↗

Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.Semantic proximity Read ↗

The emerging physiological roles of the SLC14A family of urea transporters.Semantic proximity Read ↗

Hyperuricemia and its related diseases: mechanisms and advances in therapySemantic proximity Read ↗

The effect of polymorphism of uric acid transporters on uric acid transportSemantic proximity Read ↗

An update of genetics, co‐morbidities and management of hyperuricaemiaSemantic proximity Read ↗

In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.