Article
Multiple organic anion transporters contribute to net renal excretion of uric acid.
Physiological genomics - 22 Apr 2008
Eraly Satish A, Vallon Volker, Rieg Timo, Gangoiti Jon A, Wikoff William R, Siuzdak Gary, Barshop Bruce A, Nigam Sanjay K
Abstract excerpt
Excretion of uric acid, a compound of considerable medical importance, is largely determined by the balance between renal secretion and reabsorption. The latter process has been suggested to be principally mediated by urate transporter 1 (URAT1; slc22a12), but the role of various putative urate transporters has been much debated. We have characterized urate handling in mice null for RST, the murine ortholog of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
