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Article

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies.

Clinical and experimental nephrology - 1 Feb 2012

Anzai Naohiko, Jutabha Promsuk, Amonpatumrat-Takahashi Sirirat, Sakurai Hiroyuki

Abstract excerpt

Humans have higher serum uric acid levels than other mammalian species owing to the genetic silencing of the hepatic enzyme uricase that metabolizes uric acid into allantoin. Urate (the ionized form of uric acid) is generated from purine metabolism and it may provide antioxidant defense in the human body. Despite its potential advantage, sustained hyperuricemia has pathogenetic causes in gout and renal diseases,...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Glucose Transport Proteins, Facilitative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperuricemia

Share to Kidney Tubules, Proximal

Share to Monocarboxylic Acid Transporters

Share to Organic Anion Transporters

Share to Organic Cation Transport Proteins

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Source

Identifiers

PMID: 22038265
DOI: 10.1007/s10157-011-0532-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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