Article
Control of renal uric acid excretion and gout.
Current opinion in rheumatology - 1 Mar 2008
Taniguchi Atsuo, Kamatani Naoyuki
Abstract excerpt
PURPOSE OF REVIEW: Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS: The discovery of URAT1 has facilitated identification of other molecules potentially involved in uric...
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