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Article

Renal urate handling: clinical relevance of recent advances.

Current rheumatology reports - 1 Jun 2005

Anzai Naohiko, Enomoto Atsushi, Endou Hitoshi

Abstract excerpt

Urate is the major inert end product of purine degradation in higher primates in contrast to most other mammals because of the genetic silencing of hepatic oxidative enzyme uricase. The kidney plays a dominant role in urate elimination. The kidney excretes 70% of the daily urate production. Therefore, it is important to understand renal urate handling mechanism because the under excretion of urate has been...

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PMID: 15919000
DOI: 10.1007/s11926-996-0044-0

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