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Article

<i>Comt1</i> genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice

23 Jul 2010

Abstract excerpt

Catechol-O-methyltransferase (COMT) is a ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. In humans, polymorphic variance at the COMT locus has been associated with modulation of pain sensitivity and risk for developing psychiatric disorders. A functional haplotype associated with increased pain sensitivity was shown to result in decreased COMT activity by...

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PMID: 20659173
DOI: 10.1111/j.1601-183x.2010.00633.x

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