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Article

Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.

Science (New York, N.Y.) - 22 Dec 2006

Nackley A G, Shabalina S A, Tchivileva I E, Satterfield K, Korchynskyi O, Makarov S S, Maixner W, Diatchenko L

Abstract excerpt

Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous position, code for differences in COMT enzymatic activity and are associated with pain sensitivity. Haplotypes divergent in synonymous changes exhibited the largest difference in COMT enzymatic activity,...

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Identifiers

PMID: 17185601
DOI: 10.1126/science.1131262

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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