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Article

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.

British journal of cancer - 28 Sept 2010

Baba Y, Nosho K, Shima K, Meyerhardt J A, Chan A T, Engelman J A, Cantley L C, Loda M, Giovannucci E, Fuchs C S, Ogino S

Abstract excerpt

BACKGROUND: AMP-activated protein kinase (AMPK, PRKA) has central roles in cellular metabolic sensing and energy balance homeostasis, and interacts with various pathways (e.g., TP53 (p53), FASN, MTOR and MAPK3/1 (ERK)). AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target. However, no study has examined its prognostic role...

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Share to AMP-Activated Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Extracellular Signal-Regulated MAP Kinases

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Source

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Identifiers

PMID: 20808308
DOI: 10.1038/sj.bjc.6605846
PMCID: PMC2965861

Genes

MAPK3
BRAF
FASN
KRAS
MTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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