Article
Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1.
Biochemical and biophysical research communications - 1 Oct 2010
Imanishi Miki, Imamura Chika, Higashi Chika, Yan Wei, Negi Shigeru, Futaki Shiroh, Sugiura Yukio
Abstract excerpt
In contrast to the extensive understanding of the zinc finger-DNA interactions, less is known about zinc finger-zinc finger interactions. GATA-1 and Sp1 are transcription factors with zinc finger domains for DNA binding. The interaction between the GATA-1 and Sp1 zinc finger domains is important for synergistic transcriptional effects in erythroid genes. Despite the biological importance of the GATA-1 and Sp1...
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