Article
New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites.
The EMBO journal - 15 Sept 1999
Remacle J E, Kraft H, Lerchner W, Wuytens G, Collart C, Verschueren K, Smith J C, Huylebroeck D
Abstract excerpt
SIP1, a Smad-interacting protein, and deltaEF1, a transcriptional repressor involved in skeletal and T-cell development, belong to the same family of DNA binding proteins. SIP1 and deltaEF1 contain two separated clusters of zinc fingers, one N-terminal and one C-terminal. These clusters show high sequence homology and are highly conserved between SIP1 and deltaEF1. Each zinc finger cluster binds independently to...
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