Article
The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes.
Methods (San Diego, Calif.) - 1 Jan 2002
Crispino John D, Orkin Stuart H
Abstract excerpt
With the increasing popularity of the yeast two-hybrid screen, a large number of protein-protein interactions have been identified. In many cases, single proteins have been found to associate with a large number of cofactors. For example, the hematopoietic transcription factor GATA-1 interacts with a multitude of other nuclear proteins, including Friend of GATA-1 (FOG-1), EKLF, CBP/p300, and Lmo2. Furthermore,...
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