Article
Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2005
Liew Chu Kong, Simpson Raina J Y, Kwan Ann H Y, Crofts Linda A, Loughlin Fionna E, Matthews Jacqueline M, Crossley Merlin, Mackay Joel P
Abstract excerpt
GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic development. Several naturally occurring mutations in the GATA-1 gene that alter the FOG-binding domain have been reported. The mutations are associated with familial anemias and thrombocytopenias of differing severity. To elucidate the molecular basis for the...
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