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Article

Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.

Biological & pharmaceutical bulletin - 1 Oct 1998

Matsushita K, Hagihara M, Sugiura Y

Abstract excerpt

Transcription factor Sp1 is a Cys2His2-type zinc finger protein that specifically binds to GC-boxes on numerous viral and cellular genes. In this study, we prepared several Sp1 mutant peptides Sp1 (530-696) containing zinc finger region and the domain D, and Sp1 (530--623) containing only zinc finger region, and then investigated the participation of the C-terminal domain D of Sp1 for GC-box binding. Gel mobility...

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Source

Identifiers

PMID: 9821817
DOI: 10.1248/bpb.21.1094

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Source receipt: pubmed, retrieved 7 Sept 2026.

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