Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.

doi:10.1248/bpb.21.1094

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Article

Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.

Biological & pharmaceutical bulletin - 1 Oct 1998

Matsushita K, Hagihara M, Sugiura Y

Abstract excerpt

Transcription factor Sp1 is a Cys2His2-type zinc finger protein that specifically binds to GC-boxes on numerous viral and cellular genes. In this study, we prepared several Sp1 mutant peptides Sp1 (530-696) containing zinc finger region and the domain D, and Sp1 (530--623) containing only zinc fi...

Topics

Amino Acid Sequence
Binding Sites
Binding, Competitive
DNA
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Protein Structure, Tertiary
Simian virus 40
Sp1 Transcription Factor
Tandem Repeat Sequences

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