Article
Congenic strains provide evidence that a mapped locus on chromosome 15 influences excitotoxic cell death.
Genes, brain, and behavior - 1 Feb 2011
Schauwecker P E
Abstract excerpt
Inbred strains of mice differ in their susceptibility to excitotoxin-induced cell death, but the genetic basis of individual variation is unknown. Prior studies with crosses of the FVB/NJ (seizure-induced cell death susceptible) mouse and the seizure-induced cell death resistant mouse, C57BL/6J, showed the presence of three quantitative trait loci (QTLs), named seizure-induced cell death 1 (Sicd1) to Sicd3. To...
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