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Article

Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.

The European journal of neuroscience - 1 Oct 2006

McLin Jessica Pilar, Steward Oswald

Abstract excerpt

We assessed inbred, outbred and hybrid mouse strains for susceptibility to seizures and neurodegeneration induced by systemic administration of kainic acid (KA). Each strain showed a unique pattern of susceptibility to seizures as assessed by the dose necessary to induce continuous tonic clonic seizures, progression through six seizure levels, the number of mice that failed to satisfy seizure criteria, and...

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PMID: 17074044
DOI: 10.1111/j.1460-9568.2006.05111.x

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