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Article

Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.

PloS one - 1 Jan 2014

Dietz Joel A, Maes Margaret E, Huang Shuang, Yandell Brian S, Schlamp Cassandra L, Montgomery Angela D, Allingham R Rand, Hauser Michael A, Nickells Robert W

Abstract excerpt

The Rgcs1 quantitative trait locus, on mouse chromosome 5, influences susceptibility of retinal ganglion cells to acute damage of the optic nerve. Normally resistant mice (DBA/2J) congenic for the susceptible allele from BALB/cByJ mice exhibit susceptibility to ganglion cells, not only in acute optic nerve crush, but also to chronic inherited glaucoma that is characteristic of the DBA/2J strain as they age. SNP...

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Identifiers

PMID: 24699552
DOI: 10.1371/journal.pone.0093564
PMCID: PMC3974755

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