Genetic basis of kainate-induced excitotoxicity in mice: phenotypic modulation of seizure-induced cell death.

Abstract excerpt

Excitotoxicity, a process in which excessive excitation of glutamate receptors results in cell death, has been implicated in a number of neurological disorders. However, the genetic characteristics and molecular mechanisms that can modulate the extent of cell death are unclear. Previously, we had reported that the extent of excitotoxic cell death is conferred by differences in the genetic background of several...

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