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The human <i>FLT1</i> regulatory element directs vascular expression and modulates angiogenesis pathways <i>in vitro</i> and <i>in vivo</i>

2021-03-06

Abstract excerpt

There is growing evidence that mutations in non-coding cis -regulatory elements (CREs) disrupt proper development. However, little is known about human CREs that are crucial for cardiovascular development. To address this, we bioinformatically identified cardiovascular CREs based on the occupancy of the CRE by the homeodomain protein NKX2-5 and cardiac chromatin histone modifications. This search defined a highly...

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Literature Corpus work
f93c55a0-ad72-5623-953c-0ac6a1427413
DOI
10.1101/2021.03.03.433738
Open publication

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