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The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice

25 Aug 2010

Abstract excerpt

Translational control plays a key role in late spermiogenesis. A number of mRNAs encoding proteins required for late spermiogenesis are expressed in early spermatids but are stored as translationally inactive messenger ribonucleoprotein particles (mRNPs). The translation of these mRNAs is associated with shortening of their poly(A) tail in late spermiogenesis. Poly(A)-binding protein (Pabp) plays an important...

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PMID: 20739757
DOI: 10.1172/jci43350

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