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Article

Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.

The Journal of reproduction and development - 17 Jun 2016

Kashiwabara Shin-Ichi, Tsuruta Satsuki, Okada Keitaro, Saegusa Ayaka, Miyagaki Yu, Baba Tadashi

Abstract excerpt

Mouse testes contain several isoforms of cytoplasmic poly(A)-binding proteins (PABPCs), including ubiquitous PABPC1 and testis-specific PABPC2/PABPt. PABPC2 is characterized by its absence from translationally active polyribosomes and elongating spermatids. To elucidate the function of PABPC2 in spermatogenesis, we produced mutant mice lacking PABPC2. The PABPC2-null mice showed normal fertility. The processes of...

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Source

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Identifiers

PMID: 26971890
DOI: 10.1262/jrd.2016-023
PMCID: PMC4919295

Genes

PABPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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