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Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice

28 May 2012

Abstract excerpt

Gene expression during oocyte maturation and early embryogenesis up to zygotic genome activation requires translational activation of maternally-derived mRNAs. EPAB [embryonic poly(A)-binding protein] is the predominant poly(A)-binding protein during this period in Xenopus, mouse and human. In Xenopus oocytes, ePAB stabilizes maternal mRNAs and promotes their translation. To assess the role of EPAB in mammalian...

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PMID: 22621333
DOI: 10.1042/bj20120467

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Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in micePMID 22621333Read ↗

Identification and characterization of human embryonic poly(A) binding protein (EPAB)Semantic proximity Read ↗

Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence1Semantic proximity Read ↗

An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryosSemantic proximity Read ↗

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication†Semantic proximity Read ↗

Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation.Semantic proximity Read ↗

Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte.Semantic proximity Read ↗

Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesisSemantic proximity Read ↗

The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytesSemantic proximity Read ↗

Poly(A) tail length is a major regulator of maternal gene expression during the mammalian oocyte-to-embryo transitionSemantic proximity Read ↗

Maternal mRNA deadenylation is defective in <i>in vitro</i> matured mouse and human oocytesSemantic proximity Read ↗

The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in miceSemantic proximity Read ↗

Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transitionSemantic proximity Read ↗

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