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Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis

8 Apr 2021

Abstract excerpt

Post-transcriptional regulation faces a distinctive challenge in gametes. Transcription is limited when the germ cells enter the division phase due to condensed chromatin, while gene expression during gamete maturation, fertilization, and early cleavage depends on existing mRNA post-transcriptional coordination. The dynamics of the 3'-poly(A) tail play crucial roles in defining mRNA fate. The 3'-poly(A) tail is...

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PMID: 33830517
DOI: 10.1002/bies.202000335

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