Article
Progranulin expression in the developing and adult murine brain.
The Journal of comparative neurology - 1 Oct 2010
Petkau Terri L, Neal S J, Orban P C, MacDonald J L, Hill A M, Lu G, Feldman H H, Mackenzie I R A, Leavitt B R
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition characterized by focal degeneration of the frontal and temporal lobes of the brain. Autosomal dominantly inherited mutations of the progranulin gene (GRN) have been identified as the cause of a subset of cases of familial FTLD. In order to better understand the function of progranulin in the central nervous system (CNS), we have assessed...
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