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Article

Progranulin is expressed within motor neurons and promotes neuronal cell survival

27 Oct 2009

Abstract excerpt

BACKGROUND: Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif. While inappropriate over-expression of the progranulin gene has been associated with many cancers, haploinsufficiency leads to atrophy of the frontotemporal lobes and development of a form of dementia (frontotemporal lobar degeneration with ubiquitin positive...

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PMID: 19860916
DOI: 10.1186/1471-2202-10-130

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