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Article

Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.

Cellular and molecular life sciences : CMLS - 1 Mar 2011

Kostenko Sergiy, Shiryaev Alexey, Gerits Nancy, Dumitriu Gianina, Klenow Helle, Johannessen Mona, Moens Ugo

Abstract excerpt

The mitogen-activated protein kinase-activated protein kinase-5 (MK5) resides predominantly in the nucleus of resting cells, but p38(MAPK), extracellular signal-regulated kinases-3 and -4 (ERK3 and ERK4), and protein kinase A (PKA) induce nucleocytoplasmic redistribution of MK5. The mechanism by which PKA causes nuclear export remains unsolved. In the study reported here we demonstrated that Ser-115 is an in...

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Identifiers

PMID: 20734105
DOI: 10.1007/s00018-010-0496-2
PMCID: PMC3037495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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