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Article

The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.

The Biochemical journal - 1 May 2008

Perander Maria, Aberg Espen, Johansen Bjarne, Dreyer Bo, Guldvik Ingrid J, Outzen Heidi, Keyse Stephen M, Seternes Ole-Morten

Abstract excerpt

ERK (extracellular-signal-regulated kinase) 4 [MAPK (mitogen-activated protein kinase) 4] and ERK3 (MAPK6) are atypical MAPKs. One major difference between these proteins and the classical MAPKs is substitution of the conserved T-X-Y motif within the activation loop by a single phospho-acceptor site within an S-E-G motif. In the present study we report that Ser(186) of the S-E-G motif in ERK4 is phosphorylated in...

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Identifiers

PMID: 18248330
DOI: 10.1042/BJ20071369

Genes

MAPK6
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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