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Article

Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.

Experimental cell research - 15 Oct 2004

Soma Tamotsu, Chiba Hideki, Kato-Mori Yuko, Wada Takuro, Yamashita Toshihiko, Kojima Takashi, Sawada Norimasa

Abstract excerpt

We have recently shown that cyclic AMP (cAMP) increases claudin-5 immunoreactivity along cell boundaries and could promote phosphorylation of claudin-5 on threonine residues in porcine blood-brain barrier (BBB) endothelial cells via a protein kinase A (PKA)-dependent pathway (Exp. Cell Res. 290 [2003] 275). Along this line, we identified a putative phosphorylation site for PKA at Thr(207) in the intracytoplasmic...

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Identifiers

PMID: 15383327
DOI: 10.1016/j.yexcr.2004.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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