Article
A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway.
Molecular and cellular biology - 1 Nov 2005
Seyfried Jan, Wang Xin, Kharebava Giorgi, Tournier Cathy
Abstract excerpt
The alternative splicing of the mek5 gene gives rise to two isoforms. MEK5beta lacks an extended N terminus present in MEK5alpha. Comparison of their activities led us to identify a novel mitogen-activated protein kinase (MAPK) docking site in the N terminus of MEK5alpha that is distinct from the consensus motif identified in the other MAPK kinases. It consists of a cluster of acidic residues at position 61 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.