Article
Specific proteolysis of the A-kinase-anchoring protein 149 at the Asp582 residue by caspases during apoptosis.
Oncology reports - 1 Jun 2008
Yoo Hoesook, Cha Hwa Jun, Lee Joonyoung, Yu Eun-Ok, Bae Seunghee, Jung Jin Hyuk, Sohn Insook, Lee Su-Jae, Yang Kwang-Hee, Woo Sang-Hyeok, Seo Sung-Keum, Park In-Chul, Kim Chong Soon, Jin Young-Woo, Ahn Sung K
Abstract excerpt
A-kinase-anchoring protein 149 (AKAP149) is a member of a structurally diverse, though functionally similar anchoring protein family and is localized to the outer membrane of mitochondria and in the endoplasmic reticulum-nuclear envelope network. AKAP149 plays an important role in controlling the subcellular localization and temporal specificity of protein phosphorylation and mRNA metabolism by tethering kinases...
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