Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein.

The Journal of biological chemistry - 23 Sept 2005

Profirovic Jasmina, Gorovoy Matvey, Niu Jiaxin, Pavlovic Sasa, Voyno-Yasenetskaya Tatyana

Abstract excerpt

Vasodilator-stimulated phosphoprotein (VASP) is a major substrate of protein kinase A (PKA). Here we described the novel mechanism of VASP phosphorylation via cAMP-independent PKA activation. We showed that in human umbilical vein endothelial cells (HUVECs) alpha-thrombin induced phosphorylation of VASP. Specific inhibition of Galpha13 protein by the RGS domain of a guanine nucleotide exchange factor, p115RhoGEF,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP-Binding Protein alpha Subunits, G12-G13
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoquinolines

Share to MAP Kinase Kinase Kinase 1

Share to rho-Associated Kinases

Share to Rho Guanine Nucleotide Exchange Factors

Share to Thrombin

Share to Umbilical Veins

Source

Identifiers

PMID: 16046415
DOI: 10.1074/jbc.M501361200

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein.PMID 16046415Read ↗

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.Semantic proximity Read ↗

Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.Semantic proximity Read ↗

cGMP-dependent protein kinase phosphorylates and inactivates RhoA.Semantic proximity Read ↗

Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation.Semantic proximity Read ↗

Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.Semantic proximity Read ↗

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Semantic proximity Read ↗

CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation.Semantic proximity Read ↗

GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.Semantic proximity Read ↗

A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.Semantic proximity Read ↗

Novel regulators identified by quantitative phosphoproteomics analysis during ticagrelor-induced inhibition of plateletSemantic proximity Read ↗

Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.Semantic proximity Read ↗

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.