Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity.

doi:10.1111/j.1369-1600.2010.00248.x

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Article

Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity.

Addiction biology - 1 Apr 2011

Rouault Morgane, Nielsen David A, Ho Ann, Kreek Mary Jeanne, Yuferov Vadim

Abstract excerpt

A polymorphic 68-bp tandem repeat has been identified within the promoter of the human prodynorphin (PDYN) gene. We found that this 68-bp repeat in the PDYN promoter occurs naturally up to five times. We studied the effect of the number of 68-bp repeats, and of a SNP (rs61761346) found within the repeat on PDYN gene promoter activity. Thirteen promoter forms, different naturally occurring combinations of repeats...

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PMID: 20731629
DOI: 10.1111/j.1369-1600.2010.00248.x
PMCID: PMC2995810

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PDYN

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