A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain.

doi:10.1006/bbrc.1998.8972

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Article

A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain.

Biochemical and biophysical research communications - 20 Jul 1998

Okladnova O, Syagailo Y V, Tranitz M, Stöber G, Riederer P, Mössner R, Lesch K P

Abstract excerpt

The PAX-6 gene plays a critical role in neurodevelopment and brain plasticity. While transcription of human PAX-6 is regulated by alternate usage of two distinct promoters termed A and B, expression in adult human brain is primarily controlled by promoter B. We now report that a novel polymorphic...

Topics

Alleles
Brain
DNA-Binding Proteins
Dinucleotide Repeats
Eye Proteins
Gene Expression Regulation
Genes, Reporter
Homeodomain Proteins
Humans
Nerve Tissue Proteins
PAX6 Transcription Factor
Paired Box Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Promoter Regions, Genetic

RNA, Messenger

Repetitive Sequences, Nucleic Acid

Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9675149
DOI: 10.1006/bbrc.1998.8972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9675149-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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