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Article

Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic Silencer Element

1 Dec 1998

Abstract excerpt

Induction of the prodynorphin gene has been implicated in medium and long-term adaptation during memory acquisition and pain. By 5' deletion mapping and site-directed mutagenesis of the human prodynorphin promoter, we demonstrate that both basal transcription and protein kinase A (PKA)-induced transcription in NB69 and SK-N-MC human neuroblastoma cells are regulated by the GAGTCAAGG sequence centered at position...

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Identifiers

PMID: 9819380
DOI: 10.1128/mcb.18.12.6921

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Source receipt: pubmed, retrieved 7 Sept 2026.

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