Article
Evaluation of A2BP1 as an obesity gene.
Diabetes - 1 Nov 2010
Ma Lijun, Hanson Robert L, Traurig Michael T, Muller Yunhua L, Kaur Bakhshish P, Perez Jessica M, Meyre David, Fu Mao, Körner Antje, Franks Paul W, Kiess Wieland, Kobes Sayuko, Knowler William C, Kovacs Peter, Froguel Philippe, Shuldiner Alan R, Bogardus Clifton, Baier Leslie J
Abstract excerpt
OBJECTIVE: A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity. RESEARCH DESIGN AND METHODS: Variants spanning...
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