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Article

The role of bile acid retention and a common polymorphism in the ABCB11 gene as host factors affecting antiviral treatment response in chronic hepatitis C.

Journal of viral hepatitis - 1 Nov 2011

Iwata R, Stieger B, Mertens J C, Müller T, Baur K, Frei P, Braun J, Vergopoulos A, Martin I V, Schmitt J, Goetze O, Bibert S, Bochud P-Y, Müllhaupt B, Berg T, Geier A

Abstract excerpt

The outcome of hepatitis C virus (HCV) infection and the likelihood of a sustained virological response (SVR) to antiviral therapy depends on both viral and host characteristics. In vitro studies demonstrated that bile acids (BA) interfere with antiviral interferon effects. We investigate the influence of plasma BA concentrations and an ABCB11 polymorphism associated with lower transporter expression on viral...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Acids and Salts

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Source

Identifiers

PMID: 20723035
DOI: 10.1111/j.1365-2893.2010.01363.x

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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