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Article

Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.

Pharmacogenetics and genomics - 1 Jan 2007

Lang Carmen, Meier Yvonne, Stieger Bruno, Beuers Ulrich, Lang Thomas, Kerb Reinhold, Kullak-Ublick Gerd A, Meier Peter J, Pauli-Magnus Christiane

Abstract excerpt

OBJECTIVES: Increasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the development of drug-induced liver injury. The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients...

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Source

Identifiers

PMID: 17264802
DOI: 10.1097/01.fpc.0000230418.28091.76

Genes

ABCB11
ABCB4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.PMID 17264802Read ↗

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