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Article

Variants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults.

Journal of hepatology - 1 Sept 2020

Stättermayer Albert Friedrich, Halilbasic Emina, Wrba Fritz, Ferenci Peter, Trauner Michael

Abstract excerpt

The ATP binding cassette subfamily B member 4 (ABCB4) gene on chromosome 7 encodes the ABCB4 protein (alias multidrug resistance protein 3 [MDR3]), a P-glycoprotein in the canalicular membrane of the hepatocytes that acts as a translocator of phospholipids into bile. Several variants in ABCB4 have been shown to cause ABCB4 deficiency, accounting for a disease spectrum ranging from progressive familial cholestasis...

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Source

Identifiers

PMID: 32376413
DOI: 10.1016/j.jhep.2020.04.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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